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Background: Carotid plaque is a manifestation of carotid atherosclerosis,monocytes play a key role in atherosclerosis related inflammatory response ,high density lipoprotein cholesterol (HDL-C) has vascular protective effects such as anti-inflammatory, antithrombotic and anti atherosclerosis. This study is to investigate the relationships of MHR level and the incidence of carotid artery plaque. Methods: Data of physical examination personnel in the first medical center of the General Hospital of PLA from January to April in 2018 was collected and 3848 subjects were included for retrospectively analysis. Statistical analysis was performed on Spss 22.0 0 software and statistical software R and its GAM package.Results: The difference was statistically significant in levels of MHR, body mass index (BMI), high-sensitive C-reactive protein (hs-CRP), blood lipids (HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol(TC), triglyceride(Tg)), blood glucose(Glu), Hyperglycemic hemoglobin(HbA1c), renal function (Urea, creatinine(Crea), estimated glomerular filtration rate(eGFR), Uric acid (Ua)) in carotid plaque groups (p=0.000,respectively). No significant difference between the gender (p=0.635) and age(p=0.063) in different groups. MHR levels was positively correlated with levels of BMI (r = 0.364, P = 0.000), hs-CRP (r = 0.320, P =0.000), Tg (r = 0.417, P=0.000), Crea(r=0.323, P=0.000), eGFR(r=-0.248, P=0.000), Ua(r=0.383, P=0.000) and HbA1c (r=0.197, P=0.000). Levels of TC, Glu, Urea were slightly correlated with MHR level(r=-0.150, P=0.000; r=0.187, P=0.000; r=0.137, P=0.000; respectively ). In subjects with both hypertension and diabetes, MHR levels showed difference among three groups (p=0.009). MHR level increased with elevated site number of carotid plaque in subjects without hypertension or diabetes(p=0.000). MHR level still showed differences among carotid plaque groups in subjects with hypertension and diabetes. In adjusted models, the probability of occurrence of carotid plaque increased by1.958 (95% CI: 1.144-3.351, P = 0.000) times; The probability of multiple occurrence of carotid plaques increased by 2.068 (95% CI: 1.100-3.887, P = 0.000) times. The GAM curve showed a non-linear correlation between normalized MHR and the probability of carotid plaque occurrence. Conclusions: MHR could be used as an independent risk factor and indicator for plaque formation and severity. |
