| Autor: |
T. Kaminishi, Retina Çapuni, C. Gualerzi, Sean R. Connell, B. Ochoa-Lizarralde, Paola Fucini, A. Schedlbauer, X. Han, Pohl Milón, Attilio Fabbretti |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
The ribosome is a major target for antibiotics owing to its essential cellular role in protein synthesis. Structural analysis of ribosome-antibiotic complexes provides insight into the molecular basis for their inhibitory action and highlights possible avenues to improve their potential or overcome existing resistance mechanisms. Here we use X-ray crystallography and pre-steady state kinetics to detail the inhibitory mechanism of the antimicrobial on the large ribosomal subunit. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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