| Autor: |
M. Faiz Arshad, Suroor A. Khan, Abdulmohsen H. Al Rohaimi, Nadeem Siddiqui, Ahmed Elkerdasy |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
American Journal of Pharmacology and Toxicology. 9:132-138 |
| ISSN: |
1557-4962 |
| DOI: |
10.3844/ajptsp.2014.132.138 |
| Popis: |
The present series of compounds were synthesized with the aim to develop newer anticonvulsant agents t hat are comparatively more efficacious and safer than t he currently used anticonvulsant agents. Various thiazolyl coumarins were synthesized by the reactio n of 3-(bromoacetyl)-2H-chromen-2-one with different substituted aryl thiourea. The structures of the sy nthesized compounds were confirmed by spectral data and elemental analyses. Compounds were tested for antic onvulsant activity utilizing Pen Tylenetetra Zoleinduced seizure (PTZ) and Maximal Electroshock Seizure (MES) tests at 30, 100 and 300 mg kg -1 dose level. Neurotoxicity and ethanol potentiation test of the compounds were also assessed at the same dose level. Two compounds of the series 3g and 3j exhibi ted significant anticonvulsant activity at 30 mg kg -1 dose level with lesser neurotoxicity than the stand ard drug phenytoin. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
