In-vitro activity of cefepime and seven other antimicrobial agents against 1518 non-fermentative Gram-negative bacilli collected from 48 Canadian health care facilities

Autor:	S. Borsos, J. M. Blondeau, R. Laskowski
Rok vydání:	1999
Předmět:	Pharmacology Microbiology (medical) Imipenem Cefepime Ceftazidime Biology Acinetobacter bacterial infections and mycoses biology.organism_classification Antimicrobial Microbiology Infectious Diseases Amikacin medicine Tobramycin Pharmacology (medical) Antibacterial agent medicine.drug
Zdroj:	Journal of Antimicrobial Chemotherapy. 44:545-548
ISSN:	1460-2091 0305-7453
DOI:	10.1093/jac/44.4.545
Popis:	Non-fermentative bacilli are primarily nosocomial pathogens, and are also often resistant in vitro to a broad range of antimicrobial agents. In this large Canadian study, we collected 1466 clinical, non-repeat isolates of Pseudomonas aeruginosa, 21 of Acinetobacter spp. and 31 Stenotrophomas maltophilia. MICs of eight antibiotics were determined by the NCCLS microdilution method in a central laboratory. Tobramycin was the most active agent against P. aeruginosa (94.5% susceptible); amikacin and imipenem were the most active against Acetinobacter spp. (100%) and ceftazidime was the most active against S. maltophilia (40.6%). Against each group of isolates, cefepime was active against 87, 86.4 and 15.6%, respectively. This in-vitro study showed that cefepime may be a useful additional agent in the treatment of infections caused by P. aeruginosa and Acinetobacter spp., but not when S. maltophilia is considered pathogenic.
Databáze:	OpenAIRE
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