ChemInform Abstract: Silyl Trifluoromethanesulfonate-Activated para-Methoxybenzyl Methyl Ether as an Alkylating Agent for Thiols and Aryl Ketones

Autor:	C. Wade Downey, Sarah E. Covington, Derek C. Obenschain, Danielle N. Confair, Evan Halliday, James T. Rague
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Base (chemistry) Aryl Silyl trifluoromethanesulfonate Ether General Medicine Alkylation Medicinal chemistry Silane Enol chemistry.chemical_compound chemistry Trimethylsilyl trifluoromethanesulfonate lipids (amino acids peptides and proteins)
Zdroj:	ChemInform. 46
ISSN:	0931-7597
DOI:	10.1002/chin.201508054
Popis:	para-Methoxybenzyl methyl ether acts as an alkylating agent for thiols in the presence of trimethylsilyl trifluoromethanesulfonate and trialkylamine base in good yields (58–96%). Aryl ketones are alkylated under similar conditions, probably through an enol silane intermediate, also in high yields (67–95%). The active alkylating species is likely a p-methoxybenzyl cation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bccddd31f18ac08871c44ee610078b6d https://doi.org/10.1002/chin.201508054 Zobrazit plný text záznamu Plný text