| Popis: |
The development of lymphatic tissues and immune reactivity under the limited antigenic contact in ontogeny of pigs has been reviewed by Sterzl and Kovaru (1). In the pig, as in other animal species, there are two distinct pathways of lymphoid cell differentiation leading to generation of B and T lymphocytes (2,3). First, lymphocytes which express markers of T-cell lineage (receptors for SRBC and binding sites for anti-pig T serum) appear in thymus and peripheral blood on day 38, in spleen on day 58 and react to T-cell mitogens (2,4). Surface IgM (sIgM) is a marker of B-cell lineage (5) and LPS-induced differentiation of lymphoid cells into blast-like cells in vitro starts after sIgM+ cells appear [liver — day 44, spleen — day 51 of gestation (6)]. |
