Random acrocentric bivalent associations in human pachytene spermatocytes

Autor:	M.R. Guichaoua, M. Hartung, M. Devictor, J.M. Luciani, Stahl A
Rok vydání:	1986
Předmět:	Genetics Acrocentric chromosome Chromosomal translocation Spermatocyte Biology Molecular biology Bivalent (genetics) medicine.anatomical_structure Centromere medicine Nucleolus organizer region Molecular Biology Genetics (clinical)
Zdroj:	Cytogenetic and Genome Research. 42:191-197
ISSN:	1424-859X 1424-8581
Popis:	Acrocentric bivalent associations were studied in 232 human male germ cells at pachytene in order to understand better the preferential involvement of chromosomes 13, 14, and 21 in Robertsonian translocations. The tendency of each acrocentric bivalent to associate with another was not correlated with NOR activity, as measured by silver staining. Good agreement was noticed between their ability to associate and the amount of satellite DNA in human acrocentric chromosomes. The distribution of two-by-two acrocentric bivalent associations was random. In order to reconcile this result with the nonrandom distribution of Robertsonian translocations, a molecular hypothesis is proposed. The model is based on homology of recom-binational sites, interspersed at regular interval in satellite DNA, which could increase the probability of accidental unequal crossing-over between two specific acrocentric chromosomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bcc6ecd1ed8d7cd4fb445c33b6c11bc3 https://doi.org/10.1159/000132277 Zobrazit plný text záznamu