Platelet-rich autologous plasma for the treatment of patients with grade II osteoarthritis of the knee

Autor: M. V. Demeshchenko, K. V. Baidova, S. A. Demkin, D. A. Malanin
Rok vydání: 2017
Předmět:
Zdroj: Genij Ortopedii. 23:44-51
ISSN: 2542-131X
1028-4427
DOI: 10.18019/1028-4427-2017-23-1-44-51
Popis: Introduction There have not been highly effective and equally safe tools available to relieve pain and improve joint function in patients suffering from osteoarthritis. Purpose Explore the efficacy of intra-articular application of autologous platelet-rich plasma (PRP) in the treatment of patients affected by grade 2 osteoarthritis of the knee. Material and methods The study was designed as a single-arm prospective randomized trial. A total of 60 patients with grade 2 osteoarthritis according to the J. Kellgren and J. Lawrence grading scale (1957) were enrolled in the study. Patients were divided into two clinical groups, with 30 subjects in each group. Index clinical group was treated using three 2 mL intra-articular applications of PRP performed once over a 3-week period. Control group was given three intra-articular injections of 2 mL hyaluronic acid (HA) applied once a week. Outcome measures included verbal rating scale of treatment effectiveness (VRSte), 100-point pain visual analogue scale (VAS), and Lequesne scale taken at 1-, 3-, 6- month follow-up. Results Measurement with VAS showed decrease in pain from 50.5 ± 5.38 to 9.8 ± 3.39 (p less 0.05) in index group one month after intra-articular applications of PRP. Analgetic effect persisted at a 6-month follow-up without statistically considerable changes. Control group showed decrease in pain from 46.8 ± 6.49 to 19.73 ± 5.84 (p less 0.05) scores one month after intra-articular applications of HA and decline in scores of 27.76 ± 7.72 (р less 0.05) at 6– month follow-up. Index group demonstrated considerable reduction in Lequesne score from 10.88 ± 1.63 to 4.2 ± 1.23 (p less 0.05) one month after treatment that persisted at 6-month follow-up. Control group also showed reduction in Lequesne score from 9.9 ± 1.6 to 4.7 ± 0.66 (p less 0.05) at one-month follow-up that remained nearly the same 6 months after treatment. Conclusion Our findings suggest that intra-articular application of PRP in the treatment of patients with grade 2 osteoarthritis of the knee can provide pain control and functional improvement to a greater extent as compared to HA injections throughout 6-month follow-up.
Databáze: OpenAIRE
Externí odkaz: