| Popis: |
The pathologic changes produced by excessive amounts of insulin have been studied extensively by many authors. In man, Wohlwill, 1 Doering, 2 Terplan 3 and others described lesions in the cerebral neurons following hyperinsulinism. Stief and Tokay, 4 Schmid 5 and Weil and we 6 demonstrated the damaging action of insulin on the central nervous system in experimental animals. Reports in the literature of damage to the brain following the administration of metrazol are still scarce. Strecker and his associates 7 and Stender 8 studied the changes occurring after large doses of metrazol in experimental animals. Weil and one of us (E. L.) 9 reported pathologic alterations in brains of rabbits following injection of metrazol over a long period. According to most authors, there seems to be no doubt that large doses of insulin or metrazol injected over a long period produce severe irreversible changes in the central nervous system. |
