A direct transformation of O-silyl groups into O-trichloroacetates. A novel synthetic approach to protein kinase C ligands: 1-oleoyl-2-acetyl- and 1-hexadecyl-2-acetyl-sn-glycerols

Autor:	Jacek Stawinski, Stephan D. Stamatov, Martin Kullberg
Rok vydání:	2005
Předmět:	Silylation Organic Chemistry Trichloroacetic anhydride Biochemistry chemistry.chemical_compound chemistry 1-O-hexadecyl-2-acetyl-sn-glycerol Drug Discovery Organic chemistry lipids (amino acids peptides and proteins) Glycerol Derivatives Fluoride Protein kinase C Direct transformation
Zdroj:	Tetrahedron Letters. 46:6855-6859
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2005.08.015
Popis:	A fluoride ion-promoted direct esterification of tert-butyldimethylsilyl- (TBDMS), or triisopropylsilyl (TIPS)-protected glycerol derivatives by means of trichloroacetic anhydride (TCAA), followed by removal of the trichloroacetyl transient protection, provides a new, efficient entry to stereochemically pure 1-oleoyl-2-acetyl- and 1-O-hexadecyl-2-acetyl-sn-glycerols.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bcb1a39f00cebb112c0f614fc12108f3 https://doi.org/10.1016/j.tetlet.2005.08.015 Zobrazit plný text záznamu Full Text from ScienceDirect