Preferential injury of oligodendroblasts by a short hypoxic–ischemic insult1Published on the World Wide Web on 11 November 1998.1
| Autor: | Bernhard H.J. Juurlink, Jerome Y. Yager, Susan E. Jelinski |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty Periventricular leukomalacia business.industry General Neuroscience Immunocytochemistry Ischemia Hypoxia (medical) medicine.disease medicine.disease_cause Heme oxygenase Pathogenesis White matter medicine.anatomical_structure medicine Neurology (clinical) medicine.symptom business Molecular Biology Oxidative stress Developmental Biology |
| Zdroj: | Brain Research. 815:150-153 |
| ISSN: | 0006-8993 |
| Popis: | One-week-old rat pups were subjected to an acute 10 min severe hypoxic–ischemic insult. Over the next 24 h, during the reperfusion period, O4 immunocytochemistry demonstrated that oligodendroblasts underwent degenerative changes that were coincident with induction of heme oxygenase. We suggest that the increased vulnerability of oligodendroblasts to oxidative stress following an hypoxic–ischemic insult may contribute to the pathogenesis of periventricular leukomalacia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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