| Autor: |
G. Seemann, A. Schwarz, A. Steinstraesser, H. H. Sedlacek, P. Hermentin, K. Bosslet, M. Magerstaedt, A. Bruynck, L. Kuhlmann |
| Rok vydání: |
1991 |
| Předmět: |
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| Zdroj: |
Clinical Use of Antibodies ISBN: 9789401055550 |
| DOI: |
10.1007/978-94-011-3516-0_6 |
| Popis: |
Starting from the moderate therapeutic effects of MAb guided radioimmunotherapyin the treatment of carcinomas, we presented a two phase radioimmunotherapy concept based on bispecific MAbs which might be more effective. To work out this concept we first showed that penetration into human carcinoma xenografts as well as long term storage of intact MAb outside the carcinoma cells are possible. Epitope saturation was however not yet obtained despite the large MAb doses injected i.v for 10 days. Second we generated hybridomas producing high avidity anti metal chelate MAbs (anti DTPY-Y). These hybridomas were fused with hybridomas producing MAbs selective for CEA or GIT-mucin, and stable bispecific MAb producing quadromas were obtained. THE purification of these bispecific anti Cea x anti DTPA-Y or anti GIT-mucin x anti DTPA-Y MAbs, their detailed molecular characterization and potential value we are going to work out. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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