A multicenter retrospective study to evaluate real-world clinical outcomes in patients with metastatic renal cell carcinoma (mRCC) and brain metastasis treated with ipilimumab and nivolumab
| Autor: | Wei Wei, Kimberly D Allman, Andrew J. Armstrong, Allison Martin, Julie Kephart, Landon Carter Brown, Kunal Desai, Tian Zhang, Emily N. Kinsey, Shilpa Gupta, Patrick Healy, Jorge A. Garcia, Brian I. Rini, Sundhar Ramalingam, Laura S. Wood, Michael R. Harrison, Daniel J. George, Chester Kao, Moshe Chaim Ornstein, Timothy D. Gilligan |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty business.industry Ipilimumab Retrospective cohort study medicine.disease 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma 030220 oncology & carcinogenesis Internal medicine medicine In patient Nivolumab business 030215 immunology medicine.drug Brain metastasis |
| Zdroj: | Journal of Clinical Oncology. 38:637-637 |
| ISSN: | 1527-7755 0732-183X |
| Popis: | 637 Background: The combination of ipilimumab & nivolumab (I+N) followed by maintenance nivolumab has improved outcomes in patients (pts) with mRCC. Little is known about the outcomes in mRCC pts with brain metastasis. In this multicenter retrospective analysis, we present a real-world experience in pts with brain metastasis treated with I+N. Methods: Pts with mRCC and brain metastases treated with I+N at the Duke Cancer Institute and Cleveland Clinic were identified. Pt characteristics were summarized with descriptive statistics. Fisher’s exact test was used to determine predictors of response (alpha 0.05). Results: From 10/2017 to 2/2019, 17 pts received I+N for mRCC with brain metastases. Median age was 60; 29% were female. IMDC risk was 18%/59%/24% favorable/intermediate/poor, and 77% were clear cell histology. Pts received I+N as either first-line (65%) or ≥ second-line (35%) therapy. Of the pts evaluable for response: objective response rate (ORR) was 42% [0% CR]; with 29% achieving stable disease and 18% progressive disease as their best response. Median duration on therapy was 13 weeks. 59% of pts developed an immune-related adverse event (AE). The most common reason for treatment discontinuation was disease progression (47%) followed by AEs (18%). There were no significant predictors of any radiographic response category (PR, SD, or PD) among variables assessed (gender, IMDC risk, histology, presence of bone metastasis, line of therapy, or presence of irAE). Of note, 50% (3/6) patients treated in the second-line or greater setting experienced a PR. Conclusions: In our real-world cohort of mRCC patients with brain metastasis, I+N is clinically effective. Further investigation is warranted in this population given exclusion from prior clinical trials. |
| Databáze: | OpenAIRE |
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