Antitumor effect of the conjugate of synthetic carbohydrate moiety of the tumor-associated ganglioside GM3 with hemocyanin in combination with the cytostatic cyclophosphamide

Autor:	Elena A. Khatuntseva, O. V. Kozyreva, Nikolay E. Nifantiev, E. M. Novikova, Yu. E. Tsvetkov, R. N. Stepanenko
Rok vydání:	2014
Předmět:	Ganglioside biology Chemistry medicine.medical_treatment Melanoma Hemocyanin General Chemistry Megathura crenulata biology.organism_classification medicine.disease Immune system Biochemistry biology.protein medicine Cancer vaccine Antibody Conjugate
Zdroj:	Russian Chemical Bulletin. 63:1431-1437
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-014-0614-7
Popis:	Based on the carbohydrate chains of tumor-associated ganglioside, polyvalent carbohydrate-protein conjugate 1 was synthesized suitable as a prototype of a cancer vaccine containing ∼400 residues of 3′-(N-acetyl-a-neuraminyl)lactose (3′-sialyllactose) per macromolecular complex of the hemocyanin protein of the Megathura crenulata keyhole limpet. The integrated antitumor effect of neoglycoconjugate 1 in combintion with the cytostatic cyclophosphamide was studied on the C57Bl/6 mice with transplanted melanoma B16/F0 cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bc96f0d6cb67473776c801d13dd8ecf7 https://doi.org/10.1007/s11172-014-0614-7 Zobrazit plný text záznamu Full text from SpringerLink