Ovarian Sertoli-Leydig and granulosa cell tumor: comparison of epidemiology and survival outcomes
| Autor: | Spyridon A. Mastroyannis, Emily M. Ko, A.F. Haggerty, Dimitrios Nasioudis, Nawar A. Latif |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
End results medicine.medical_specialty 030219 obstetrics & reproductive medicine business.industry Granulosa cell Confounding Obstetrics and Gynecology Cancer Ovary General Medicine medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine Epidemiology Medicine business Sertoli-Leydig Cell Tumor Sex Cord-Stromal Tumor |
| Zdroj: | Archives of Gynecology and Obstetrics. 302:481-486 |
| ISSN: | 1432-0711 0932-0067 |
| DOI: | 10.1007/s00404-020-05633-z |
| Popis: | To investigate the epidemiology, clinico-pathological characteristics and outcomes of patients diagnosed with malignant ovarian Sertoli-Leydig cell tumors (SLCTs) in comparison to granulosa cell tumors (GCTs). The National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database were accessed and patients diagnosed with a malignant SLCT and GCT between 1988 and 2013 were selected. Demographic and clinico-pathological characteristics were compared using the Mann–Whitney and chi-square tests. Overall (OS) and cancer-specific survival (CSS) rates were estimated with the Kaplan–Meier method and compared with the log-rank test. Cox hazard models were constructed to control for confounders. A total of 175 and 1361 patients diagnosed with SLCT and GCT, respectively, were identified. Compared to patients with GCT, those with SLCT were younger (median age 32 vs. 51 years, p 10 cm), SCLTs were associated with a worse cancer-specific mortality compared to GCTs. SLCTs are extremely rare, commonly arise in premenopausal patients. They are associated with a poorer prognosis compared to GCT. |
| Databáze: | OpenAIRE |
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