Preoperative Six-Minute-Walk Test in Lung Transplantation: survival predictor
| Autor: | Nídia Caires, Sara Campos Silva, Luísa Semedo, Ivan Bravio, Fernando Martelo, Rita Gerardo, José Fragata, João Cardoso, Nicole Murinello, Alexandra Borba, Ana Sofia Santos, João Eurico Reis, Vania Caldeira, Paulo Calvinho |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Percentile Lung business.industry medicine.medical_treatment Interstitial lung disease Retrospective cohort study 030204 cardiovascular system & hematology medicine.disease Test (assessment) Log-rank test 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030228 respiratory system Internal medicine Statistical significance medicine Lung transplantation business |
| Zdroj: | Transplantation. |
| DOI: | 10.1183/1393003.congress-2017.pa1549 |
| Popis: | Introduction: The 6-minute-walk test (6MWT) is a reproducible and commonly used test that evaluates exercise capacity in patients with severe pulmonary disease. The test results are considered predictors of survival in different pulmonary diseases. Objective: To evaluate the preoperative 6MWT results as predictors of postoperative survival in lung transplant recipients. Methods: A retrospective study of 97 consecutive, adult lung transplant recipients transplanted at our centre from 2009 to 2016. Kaplan-Meier methods and log rank test were used to determine the association between preoperative 6MWT results and post-transplant survival. Results: A total of 79 patients were included, with a mean age of 48 years (SD 13), 46 (58.2%) males, with the most common indication being interstitial lung disease (46.8%). Preoperatively, the median FEV1 was 1020 mL (33.8%), median 6-minute-walk distance (6MWD) was 296m (25th–75th percentiles =180-389 m) and oxygen desaturation was 12% (25th–75th percentiles =7-20%). The median survival was 66,46 months. Walking distance 20%) was also associated with lower survival but without statistical significance (mean 55 vs 70 months, p=0.94). Conclusions: In our group 6MWD, but not oxygen desaturation, was significantly associated with post-transplant survival. This finding may have important implications for the assessment and stratification of individual risk/benefit ratio before proceeding to lung transplantation. |
| Databáze: | OpenAIRE |
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