Antimicrobial Action of Terramycin in Vitro and in Vivo
| Autor: | Nancy Dougherty, Tulita F. Lenert, Mary Kiseluk, Gladys L. Hobby, Elizabeth Hudders |
|---|---|
| Rok vydání: | 1950 |
| Předmět: |
Gram-negative bacteria
biology medicine.drug_class Hydrochloride Gram-positive bacteria Antibiotics Oxytetracycline Antimicrobial biology.organism_classification General Biochemistry Genetics and Molecular Biology In vitro Microbiology chemistry.chemical_compound chemistry In vivo medicine medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 73:503-511 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-73-17727 |
| Popis: | Discussion and SummaryThe data reported in this and in a previous communication by Finlay et al.(1) emphasize the strong antimicrobial activity of terramycin and its salts against a wide variety of aerobic and anaerobic gram-positive and gram-negative bacteria, and against certain of the rickettsiae. In addition, attention is called to the possible tuberculostatic activity of this compound. Terramycin is absorbed readily following oral or parenteral administration and is a highly effective chemotherapeutic agent, active against a variety of experimental infections in mice. A comparative study of the chemotherapeutic activities of terramycin and its salts indicates that the highly insoluble amphoteric form of terramycin as well as its more soluble salts are all chemotherapeutically effective. In most instances, the CD50 of the hydrochloride has been less than that of the other forms of terramycin, especially when administered by the oral route. More satisfactory results, as indicated by lower CD50 values, ... |
| Databáze: | OpenAIRE |
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