Radiation-Induced Formation of a Crosslink between Base Moieties of Deoxyguanosine and Thymidine in Deoxygenated Solutions of d(CpGpTpA)

Autor:	Edwin E. Budzinski, Jason S. Gobey, Harold C. Box, John C. Wallace, Jean D. Dawidzik, Marianne S. Evans
Rok vydání:	1996
Předmět:	chemistry.chemical_classification Radiation Aqueous solution Guanine Radiochemistry Biophysics Photochemistry Thymine Lesion chemistry.chemical_compound chemistry Covalent bond medicine Deoxyguanosine Molecule Radiology Nuclear Medicine and imaging Nucleotide medicine.symptom
Zdroj:	Radiation Research. 145:641
ISSN:	0033-7587
Popis:	A new type of tandem base lesion has been observed in d(CpGpTpA) X-irradiated in aqueous solution. The lesion is attributed to the formation of a covalent bond between the C8 carbon atom of guanine and the methyl carbon atom of thymine. This tandem base lesion is formed in the absence of oxygen. It is the main product produced by ionizing radiation under these conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bc8b719a8acf050635119fcc9ce7f0c4 https://doi.org/10.2307/3579285 Zobrazit plný text záznamu