Phase 1/2a study of once daily oral BAL101553, a novel tumor checkpoint controller (TCC), in adult patients with advanced solid tumors

Autor:	Stephanie Anderson, Donna Crawford, Caterina Aversa, Michael-John Devlin, Alison L. Hannah, Rebecca Kristeleit, Heidi Lane, T.R. Jeffry Evans, Phil McKernan, Felix Bachmann, R. Rulach, Elizabeth Ruth Plummer, Patrice Larger, Marc Engelhardt, Manolo D'Arcangelo, Juanita Lopez, Noor Md Haris, Alvaro Henrique Ingles Garces, Rowan Miller, Thomas Kaindl
Rok vydání:	2018
Předmět:	Cancer Research Adult patients business.industry Prodrug Small molecule Spindle checkpoint Oncology Microtubule Control theory Tumor cell death Cancer research Medicine Once daily business
Zdroj:	Journal of Clinical Oncology. 36:2530-2530
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2018.36.15_suppl.2530
Popis:	2530Background: BAL101553 is the prodrug of BAL27862, a small molecule TCC that binds microtubules and promotes tumor cell death by activation of the spindle assembly checkpoint. In a study of BAL1...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bc8ac8e3ecd7097a6f9ace2cbbe60496 https://doi.org/10.1200/jco.2018.36.15_suppl.2530 Zobrazit plný text záznamu