ChemInform Abstract: Design, Synthesis and Cytotoxicity of Novel Podophyllotoxin Derivatives

Autor:	Min Li, Jing Wang, Zhi-Yong Lei, Maosheng Cheng, Bo Cao, Chun-Xian He, Pengfei Yu, Na Yang, Hong Chen
Rok vydání:	2008
Předmět:	Podophyllotoxin Podophyllotoxin derivatives Design synthesis Chemistry In vitro cytotoxicity medicine General Medicine Association strategy Cytotoxicity Combinatorial chemistry Human cancer medicine.drug
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200847220
Popis:	A series of novel podophyllotoxin derivatives were designed using association strategy and synthesized by coupling either podophyllotoxin (1) or 4β-amino podophyllotoxin (3) with substituted indol-3-yl-glyoxyl chlorides. Their structures were identified using spectroscopic techniques. These novel derivatives have been evaluated for cytotoxicity in vitro against four human cancer cell lines with comparison to the parent compounds 1, 3 and indibulin (2). Some of the compounds (7a, 7c) showed comparable cytotoxicity to that of podophyllotoxin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bc88f1f3010e069b157f8559a770cbd6 https://doi.org/10.1002/chin.200847220 Zobrazit plný text záznamu Plný text