Reversible centriole depletion with an inhibitor of Polo-like kinase 4

Autor:	Amir Motamedi, Karen Oegema, Andrew K. Shiau, Jennifer W. Mitchell, Sun K. Kim, Michelle Yoon, John V. Anzola, Brian J. Mitchell, Chanmee P. Seo, Timothy C. Gahman, Ashley V. Kroll, Judy E. Hsia, Robert L. Davis, Yao Liang Wong, Arshad Desai
Rok vydání:	2015
Předmět:	PLK4 Multidisciplinary Centriole Hippo signaling Centrosome Cancer cell Polo-like kinase Biology Mitosis Centriole assembly Cell biology
Zdroj:	Science. 348:1155-1160
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.aaa5111
Popis:	Giving an old organelle the old heave-ho Centrioles are ancient cellular organelles that build centrosomes, the major microtubule-organizing centers in animal cells. Duplication of centrioles is tightly controlled to ensure that each dividing cell has precisely two centrosomes. Human cancer cells often have extra centrosomes, which has been hypothesized to confer a proliferative advantage. Wong et al. developed small molecules (centrinones) that allowed them to reversibly “delete” centrioles from cells (see the Perspective by Stearns). Surprisingly, cancer cells continued to divide in the absence of centrosomes, whereas normal cells stopped dividing. Science , this issue p. 1155 ; see also p. 1091
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bc868d8d5d3b8c220d55869e6996fbff https://doi.org/10.1126/science.aaa5111 Zobrazit plný text záznamu Plný text ve formátu PDF