The association of histologic grade with acute graft-versus-host disease response and outcomes
| Autor: | Rabi Hanna, Donna Abounader, Navneet S. Majhail, Mayur Narkhede, Brian J. Bolwell, Brad Pohlman, Aaron T. Gerds, Brian T. Hill, Robert M. Dean, Hien D. Liu, Ronald Sobecks, Matt Kalaycio, Betty K. Hamilton, Lisa Rybicki, Deepa Jagadeesh |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.diagnostic_test business.industry Hematology Disease medicine.disease Comorbidity Gastroenterology Transplantation 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Histologic grade Internal medicine Severity of illness Biopsy Medicine Young adult business 030215 immunology Cause of death |
| Zdroj: | American Journal of Hematology. 92:683-688 |
| ISSN: | 0361-8609 |
| Popis: | Consensus criteria are routinely used to clinically grade acute graft-versus-host disease (GVHD). A histologic grading system for acute GVHD is available, but there are limited data on its correlation with clinical grade and hematopoietic cell transplantation (HCT) outcomes. Among 503 patients who underwent allogeneic HCT from 2005 to 2013, we identified 300 biopsy episodes of the skin and gastrointestinal (GI) tract in 231 patients. Histologic grade was correlated with clinical grade of GVHD, day 28 treatment response, and outcome. Both skin (R = 0.32) and GI (R = 0.61) histologic grade correlated with clinical grade (P |
| Databáze: | OpenAIRE |
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