Peculiarities of inflammatory process and markers of inflammation in patients with bronchial asthma and COPD
| Autor: | V G Timchik, N A Filippova, K V Negrutsa, E V Gorovneva, V I Trofimov, G B Fedoseev, K N Kryakunov, V A Alexandrin, T S Razumovskaya, I V Birulya |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Russian Journal of Allergy. 11:44-58 |
| ISSN: | 2686-682X 1810-8830 |
| DOI: | 10.36691/rja514 |
| Popis: | The investigation concerned the diagnostic value of following inflammation markers in patients with mild or moderate bronchial asthma (BA), chronic obstructive pulmonary disease (COPD), chronic bronchitis and pneumonia: expired air nitric oxide (Feno) and serum levels of α 1-antitripsin and neutrophilic elastase. 93 patients were included: 6 with mild BA, 11 - with moderate BA, 17 - with mild BA and chronic bronchitis, 25 - with moderate BA and COPD, 25 - with COPD, 9 - with pneumonia. The control group consisted of 21 healthy donors. We revealed that Feno, α 1-antitripsin and neutrophilic elasthase indicate the presence of the inflammation: Feno elevation mostly related to allelrgic one, α 1-antitripsin and neutrophilic elasthase - to infection-dependent inflammation. Treatmentinduced remission of the disease leads to the decrease of α 1-antitripsin and neutrophilic elasthase, but levels are not reaching the normal values. This confirms the presence of airways inflammation during clinical remission of the disease. Elevated levels of α 1-antitripsin and neutrophilic elasthase are associated with the decreased forced expiratory volume during the first second (FEV 1 - % to the predicted values). |
| Databáze: | OpenAIRE |
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