Hydration behavior of heart muscle studies by nuclear magnetic relaxation: Deuterium exchange of water protons in the myocardium
| Autor: | Peter J. Bechtel, Ion C. Baianu, Jeonghae Rho. Lee |
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| Rok vydání: | 1999 |
| Předmět: |
Nuclear magnetic relaxation
Polymers and Plastics Ion exchange Proton Chemistry Quantitative Biology::Tissues and Organs Physics::Medical Physics Organic Chemistry Chemical exchange Intermolecular force Condensed Matter Physics Dipole Nuclear magnetic resonance Deuterium Materials Chemistry Hydrogen–deuterium exchange Nuclear Experiment |
| Zdroj: | Macromolecular Symposia. 140:245-261 |
| ISSN: | 1022-1360 |
| DOI: | 10.1002/masy.19991400125 |
| Popis: | Proton transverse relaxation, deuterium and oxygen-17 NMR measurements on functional animal heart muscle were employed to study the distribution and exchange of water protons in the heart. Our nonlinear regression analysis of such data showed the presence of three proton transverse relaxation components that are likely to correspond, respectively, to two major types of water compartments in the heart muscle and the heart muscle matrix. A deuterium exchange study was undertaken to obtain additional information concerning the chemical exchange of water protons/deuterium within these two water compartments, and the effects of proton intermolecular dipolar interactions on the transverse relaxation of water protons. Our results are likely to influence the analysis and interpretation of MRI data for myocardium since it provides details of the microscopic water distribution in the myocardium which is important to the heart function. |
| Databáze: | OpenAIRE |
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