Enhancement of Interleukin-2 Production in CCRF-CEM, Human T-Cell Leukemia, by Tea Flavonols
| Autor: | Mari Maeda-Yamamoto, Kazumi Asai, Sawako Moriwaki |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Interleukin 2 Ecology Pokeweed mitogen Interleukin Stimulation Molecular biology chemistry.chemical_compound Flavonols chemistry Biochemistry hemic and lymphatic diseases medicine Animal Science and Zoology Myricetin Kaempferol Quercetin Agronomy and Crop Science Biotechnology medicine.drug |
| Zdroj: | Japan Agricultural Research Quarterly: JARQ. 39:51-55 |
| ISSN: | 2185-8896 0021-3551 |
| DOI: | 10.6090/jarq.39.51 |
| Popis: | Human T-cell leukemia, CCRF-CEM, produced interleukin (IL)-2 stimulated with phorbol myristate acetate (PMA) and pokeweed mitogen (PWM). In PMA/PWM stimulation, IL-2 production in CCRF-CEM was increased by treatment with kaempferol or quercetin, tea (Camellia sinensis L.) flavonols. In this study, we concluded that (1) flavonols affected the expression of CCRF-CEM surface molecules, (2) CCRF-CEM was activated by flavonols, achieving a state receptive to stimulation, and (3) IL-2 production and mRNA expression were promoted by flavonols. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|