Quality assurance for PET gas production using the Cyclone 3D oxygen-15 generator

Autor:	M Ghyoot, DB Mackay, K. Poole, F Schmitz, S McKnight, CJ Steel, R. Verbruggen, Yves Jongen, F Vamecq
Rok vydání:	1999
Předmět:	Radiation Chemistry business.industry Generator (category theory) Cyclotron Analytical chemistry chemistry.chemical_element Molecular sieve Oxygen law.invention law Total nitrogen business Quality assurance
Zdroj:	Applied Radiation and Isotopes. 51:403-409
ISSN:	0969-8043
DOI:	10.1016/s0969-8043(99)00063-9
Popis:	The production and quality control analysis of short-lived (t(1/2)=2.03 min) oxygen-15 labelled gases ([O-15]O-2, [O-15]CO, and [O-15]CO2) from a Cyclone 3D accelerator for positron emission tomography (PET) in human subjects has been established and evaluated on a routine basis use at the MRC Cyclotron Unit and are here described. Contaminant levels have been identified and measured by radio-gas chromatography. The maximum levels allowed, measured as a percentage of total delivered activity (v/v), are 3.7% for total nitrogen oxides and 1% for [O-15]CO in [O-15]CO2 and [O-15]CO2 in [O-15]CO. By adjunction of a cryogenic or molecular sieve trap, radiopharmaceutical gases are routinely produced well within these specifications. (C) 1999 Elsevier Science Ltd. All rights reserved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bc71b0e982ef178140561e5713ea9c46 https://doi.org/10.1016/s0969-8043(99)00063-9 Zobrazit plný text záznamu Full Text from ScienceDirect