Bicyclic Nucleoside Inhibitors of Varicella—Zoster Virus: 5′-Chloro and 3′-Chloro Derivatives
Autor: | Christopher McGuigan, G Luoni, E. De Clercq, Jan Balzarini, Graciela Andrei, Robert Snoeck |
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Rok vydání: | 2004 |
Předmět: | |
Zdroj: | ChemInform. 35 |
ISSN: | 1522-2667 0931-7597 |
Popis: | We have recently discovered bicyclic furopyrimidines as potent and selective inhibitors of VZV. In order to investigate the structural requirements for antiviral activity we have succesfully synthesised some 3′-chloro and 5′-chloro derivatives. The compounds have been tested against VZV and CMV, but displayed no significant in vitro activity. |
Databáze: | OpenAIRE |
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