Nuclear antigen–reactive CD4+ T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys
| Autor: | Nina Babel, Gabriela Riemekasten, Falk Hiepe, Gerd-Rüdiger Burmester, Jens Y Humrich, Ulrik Stervbo, Christian Meisel, Sebastian Tesch, Petra Bacher, Andreas Radbruch, Anna-Sophie Grießbach, Alexander Scheffold, Tobias Alexander, Philipp Enghard, D Abdirama, Caroline von Spee-Mayer, Kai-Uwe Eckardt, Robert Biesen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Autoimmune disease Effector business.industry T cell 030232 urology & nephrology Lupus nephritis medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Disease severity Antigen Nephrology Antigen specific Immunology medicine business Infiltration (medical) |
| Zdroj: | Kidney International. 99:238-246 |
| ISSN: | 0085-2538 |
| DOI: | 10.1016/j.kint.2020.05.051 |
| Popis: | Systemic lupus erythematosus is a systemic and chronic autoimmune disease characterized by loss of tolerance towards nuclear antigens with autoreactive CD4+ T cells implicated in disease pathogenesis. However, very little is known about their receptor specificity since the detection of human autoantigen specific CD4+ T cells has been extremely challenging. Here we present an analysis of CD4+ T cells reactive to nuclear antigens using two complementary methods: T cell libraries and antigen-reactive T cell enrichment. The frequencies of nuclear antigen specific CD4+ T cells correlated with disease severity. These autoreactive T cells produce effector cytokines such as interferon-γ, interleukin-17, and interleukin-10. Compared to blood, these cells were enriched in the urine of patients with active lupus nephritis, suggesting an infiltration of the inflamed kidneys. Thus, these previously unrecognized characteristics support a role for nuclear antigen-specific CD4+ T cells in systemic lupus erythematosus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|