Acute myeloid leukaemia relapsing after allogeneic haemopoietic stem cell transplantation: prognostic factors and impact of initial therapy of relapse
| Autor: | David J. Curtis, Matthew Greenwood, Andrew Lim, Ian Bilmon, Cameron Curley, Jeff Szer, Marnie Collins, Mark Hertzberg, Duncan Purtill, Glen A Kennedy, Bartlomiej Getta, Ashanka Beligaswatte, Matthew Wright, John Moore, Tasman Armytage, John Gibson, Kate Mason, Chun Yew Fong, David Ritchie, Ian D. Lewis, Katherine Fielding, Anne Maree Johnston |
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| Rok vydání: | 2018 |
| Předmět: |
Oncology
medicine.medical_specialty Myeloid business.industry medicine.medical_treatment Hazard ratio Salvage therapy Hematopoietic stem cell transplantation Donor lymphocyte infusion Surgery Radiation therapy Transplantation 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine Internal Medicine medicine business Survival rate 030215 immunology |
| Zdroj: | Internal Medicine Journal. 48:276-285 |
| ISSN: | 1444-0903 |
| Popis: | BACKGROUND/AIMS: We sought to determine factors associated with the overall survival from relapse (OSR) of acute myeloid leukaemia (AML) after allogeneic haemopoietic stem cell transplantation (alloHSCT) and the effect of first salvage therapy and subsequent graft-versus-host disease (GVHD) on OSR. METHODS: Data on 386 patients from nine Australian centres with relapsed AML post-alloHSCT were collected retrospectively. OSR was calculated using the Kaplan-Meier method. Univariate and multivariate analyses were conducted using the log-rank test and proportional hazards modelling, respectively and a prognostic index for OSR was derived from multivariate modelling. RESULTS: On multivariate analysis, relapse within 6 months (hazard ratio (HR) 2.4, P |
| Databáze: | OpenAIRE |
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