| Autor: |
Kazushige Isono, Tadashi Ogasawara, Chiaki Furutani, Hironao Asahina, Yoshiyuki Okada, Masahiro Irifune, Hironori Miyazaki, Sara J Jarvis, Yudai Higuchi, Kota Miyahara, Yuki Oda |
| Rok vydání: |
2020 |
| Předmět: |
|
| DOI: |
10.21203/rs.3.rs-118455/v1 |
| Popis: |
Local anesthesia with vasoconstrictor-free mepivacaine is known to not evoke pressor responses. However, it is unknown whether baroreflex function and blood pressure (BP) fluctuations are preserved by using mepivacaine. We tested the hypothesis that mepivacaine reduces baroreflex sensitivity (BRS) without changing its operating point. Beat-by-beat BP, heart rate (HR), and muscle sympathetic nerve activity (MSNA) were measured upon injection of either saline (CNT) or 3% mepivacaine (MPV) in the apical regions of the premolars and around the mandibular foramen in 10 healthy young men [23±5 (SD) years]. Cardiac and sympathetic BRSs were assessed by bolus injections of sodium nitroprusside followed by phenylephrine HCl, and then determined from the slopes of regression lines between systolic BP and HR and between diastolic BP and MSNA, respectively. HR was significantly higher in MPV than CNT (P0.05). Moreover, neither cardiac nor sympathetic BRS in CNT were altered by MPV (−0.71±0.13 vs. −0.78±0.33 beats·min−1·mmHg−1, P=0.41; −0.98±0.35 vs. −0.92±0.16 units･beat−1･ mmHg−1, P=0.73). Cardiac and sympathetic baroreflex functions were preserved and BP fluctuation may be well maintained under local anesthesia using vasoconstrictor-free 3% mepivacaine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
