Lymphocyte Phosphodiesterase Activity in Bronchial Asthma
| Autor: | Kimiyo Yamasaki, Mitsuo Ohishi, Kentaroh Ohkawa, Shigenori Nakajima, Ryuta Haraguchi |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty business.industry Lymphocyte Phosphodiesterase Xanthine medicine.disease Adenosine receptor respiratory tract diseases chemistry.chemical_compound Endocrinology medicine.anatomical_structure Enzyme chemistry Internal medicine medicine Theophylline business Intracellular medicine.drug Asthma |
| Zdroj: | Nihon Kikan Shokudoka Gakkai Kaiho. 44:449-455 |
| ISSN: | 1880-6848 0029-0645 |
| DOI: | 10.2468/jbes.44.449 |
| Popis: | Phosphodiesterase is the only enzyme that catalyzes the hydrolysis of cyclic AMP to 5′AMP, and the relaxation of smooth muscle is the result of an intracellular increase in the level of cyclic AMP. It has been generally assumed that the bronchodilatory properties of theophylline in asthma therapy are due to its cyclic AMP-phosphodiesterase inhibitory capacity. In recent years, a number of studies on the action of theophylline have led to a general hypothesis which suggests that xanthine derivatives act as adenosine receptor antagonists. In the present study, we reported that the lymphocyte cyclic AMP level showed an obvious increase only in asthma patients after the administration of theophylline, while the level was the same in asthma patients and healthy adults before this administration.The difference in phosphodiesterase activity between patients and healthy adults in one of the causes of the difference in the lymphocyte cyclic AMP level.In this study, we examined lymphocyte phosphodiesterase activity and the following results were obtained.1) The lymphocyte phosphodiesterase activity was higher in patients with bronchial asthma than in healthy adults.2) The lymphocyte phosphodiesterase activity level showed an obvious decrease only in patients with asthma.These results suggest that phosphodiesterase activity is related to the mechanism of bronchial asthma, and the hypothesis that theophylline is an inhibitor of phosphodiesterase is confirmed. |
| Databáze: | OpenAIRE |
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