Scaling continuous API synthesis from milligram to kilogram: extending the enabling benefits of micro to the plant

Autor:	Juliana M. de Souza, D. Tyler McQuade, Mateo Berton, David R. Snead, Irini Abdiaj
Rok vydání:	2020
Předmět:	Fluid Flow and Transfer Processes Plug flow Kilogram 010405 organic chemistry Computer science Continuous flow business.industry Process chemistry Organic Chemistry Mixing (process engineering) 010402 general chemistry 01 natural sciences 0104 chemical sciences Pilot plant Chemistry (miscellaneous) Process engineering business Scaling
Zdroj:	Journal of Flow Chemistry. 10:73-92
ISSN:	2063-0212 2062-249X
DOI:	10.1007/s41981-019-00060-x
Popis:	The signature benefits of continuous flow are largely a result of a reactor’s micro-sized features. However, as the technology gains industrial traction in the synthesis of active pharmaceutical ingredients (API), the reactors must be scaled to larger size to meet production demands. Often, the micro-features cannot be preserved, and thus the challenge is in transferring the benefits of micro to the pilot plant and beyond. This review presents solutions to typical problems encountered in plug flow reactors (PFR) related to heat transfer, mixing, handling biphasic reactions, and photochemistry. Lessons are taken from kilogram level syntheses developed in pharmaceutical process chemistry groups.
Databáze:	OpenAIRE
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