Phthalates in the NICU: Is it safe?
| Autor: | C. Fischer, Jean-François Tolsa, D Palmero, Vincent Muehlethaler, Myriam Bickle Graz |
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| Rok vydání: | 2013 |
| Předmět: |
Parenteral Nutrition - Associated Cholestasis
Pediatrics medicine.medical_specialty Pregnancy business.industry Phthalate MEDLINE Environmental exposure medicine.disease chemistry.chemical_compound chemistry Pediatrics Perinatology and Child Health medicine Observational study Reproductive toxicity business Medical literature |
| Zdroj: | Journal of Paediatrics and Child Health. 49:E413-E419 |
| ISSN: | 1034-4810 |
| DOI: | 10.1111/jpc.12244 |
| Popis: | Aims As growing concerns exist regarding phthalate exposure, which could be teratogenic, carcinogenic or induce reproductive toxicity, we aimed to review the evidence of the risks due to the use of medical devices containing di(2-ethylhexyl)phthalate in hospitalized neonates. Methods We reviewed the literature, searching through medical literature databases (Pubmed, MEDLINE, EBM reviews, Cochrane database, Embase and Google Scholar) using the following keywords: phthalate, di(2-ethylhexyl)phthalate, newborn and neonate. Results We identified several associations with short and long term health dangers, mainly subfertility, broncho-pulmonary dysplasia, necrotising enterocolitis, parenteral nutrition associated cholestasis and neuro-developmental disorders. These data are based mainly on animal or observational human studies. Conclusion Clinicians must be aware of the potential risks due to phthalate exposure in the NICU. Di(2-ethylhexyl)phthalate containing materials should be identified and alternative devices should be considered. There is a need to improve knowledge in this area. |
| Databáze: | OpenAIRE |
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