Antioxidant and Immunotropic Properties of some Lithium Salts
| Autor: | Elena V. Dorozhko, Elena Korotkova, Nikolay A. Bokhan, Svetlana A. Ivanova, Astashkina Ap, Olesya Voronova, Irina Martemianova, Evgeniy Vladimirovich Plotnikov, Dmitrii Martemianov, Wolfgang Linert |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Antioxidant Lithium (medication) Chemistry Radical Phagocytosis medicine.medical_treatment Glutamate receptor Medicine (miscellaneous) Stimulation Lithium Benzoate 03 medical and health sciences 030104 developmental biology Immune system Biochemistry medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics medicine.drug |
| Zdroj: | Journal of Applied Pharmaceutical Science. :086-089 |
| ISSN: | 2231-3354 |
| Popis: | Article history: Objective: The antioxidant activity and immuno-tropic effects of lithium glutamate, lithium salicylate, lithium benzoate and lithium lactate have been investigated in this work, as a base for new psychotropic medicines. Methods: The antioxidant properties were studied by the voltammetric method. Phagocytic activity of neutrophilic leucocytes and the reaction of blastic transformation of lymphocytes were used as test for assessments of influence of the lithium compounds on the immune cells of human blood. Results: It was revealed absence of toxic action on human blood cells for all tested substances. Lithium benzoate showed the most significant stimulating influence on lymphocytes. Glutamate and benzoate lithium expressed scavenging activity vs oxygen radicals. Salicylate and benzoate lithium revealed significant phagocytosis stimulation effects. Conclusion: Investigated lithium salts expressed antioxidant activity and immunotropic effects, all investigated substance are of interest in medical application for mental diseases and comorbid pathology treatment. |
| Databáze: | OpenAIRE |
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