ChemInform Abstract: SAR Studies of Diaryltriazoles Against Bacterial Two-Component Regulatory Systems and Their Antibacterial Activities

Autor:	Glenda C. Webb, Michael Loeloff, Dennis J. Hlasta, Raul Goldschmidt, Jihua Guan, Barbara D. Foleno, Mark J. Macielag, Zhihua Sui, John F. Barrett
Rok vydání:	2010
Předmět:	Chemistry Triazole derivatives medicine Pathogenic bacteria General Medicine Whole cell medicine.disease_cause Microbiology
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
Popis:	A series of diaryltriazole analogs was discovered to inhibit bacterial two-component regulatory systems in our primary assays, KinA/SpoOF and NRII/NRI. They also showed inhibitory activity in whole cell mechanism-based assays, and they possessed potent activities against several strains of Gram-positive pathogenic bacteria in the standard MIC broth assay.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bc286cf06ffd0f3a44459f6199a68f49 https://doi.org/10.1002/chin.199847288 Zobrazit plný text záznamu Plný text