| Autor: |
F. Innocenti, E. Cellai, G. Bellesi, M.G. Papi, Rossi Ferrini, Renato Alterini, F. Rossi, Gianpaolo Biti, M.A. Spediacci, Stefano Maria Magrini, S. Stefanacci, L. Riaacci |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
European Journal of Cancer. 32:S13 |
| ISSN: |
0959-8049 |
| DOI: |
10.1016/0959-8049(96)84817-9 |
| Popis: |
Owing to the good results obtained nowadays with the treatment of HD, a large number of long term survivors may be studied to better define “high risk” and “low risk” cases, to tailor treatment at presentation according to the available prognostic factors. Large series coming from single, Institutions include patients (pts) treated according to a more homogeneous clinical behaviour and the resulting data analysis is therefore more accurate. The Radiotherapy (RT) and Hematology (HE) Departments of the University of Florence (UF) walked togheter in the management of HD during the last 20 years and decided to pool togheter their clinical material for analysis. This report analyzes the effect of the different prognostic factors and of the therapeutic options adopted at presentation on survival (actuarial uncorrected, corrected and relapse free) and on the incidence of jatrogenic damage, for the stage III cases staged with laparotomy and splenectomy (pathologic stage, PS). In particular. the prognostic impact of the anatomic substaging (III I and III2 substages) of these patients will be analyzed. Between 1970 and 1991. 1261 pts have been treated at the UF. Of them, 219 have been staged as PS III cases. The main clinico-therapeutic features of this subgroup are as follow: Gender: M 138. F 81; Age: 50 yrs= 35; Clin. Stage: I = 10; II = 97; 111 = 112; Path. Stage:III1= 126; III2= 93 Systemic symptoms: A = 154; B = 65; Histology: LP - 22; NS = 83; MC = 101; DL = 8; No subtype = 5; Treatment at presentation: IIIl pts: RT=67; RT+CHT=26; CHT=26; III2 pts: RT: 24; RT+CHT=38; CHT=31. Among the 219 cases treated we observed 100 relapses; 49 patients deceased because of Hodgkin's disease, 51 have been salvaged with second line treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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