An algorithm for testing and reporting serum choriogonadotropin at clinically significant decision levels with use of 'pregnancy test' reagents
| Autor: | Z L Bandi, M Waters, Irwin Schoen |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Pregnancy test
Gynecology endocrine system medicine.medical_specialty Pregnancy business.industry Biochemistry (medical) Clinical Biochemistry INT Trophoblast Elisa assay medicine.disease medicine.anatomical_structure medicine Gestation Clinical decision business Algorithm hormones hormone substitutes and hormone antagonists |
| Zdroj: | Clinical Chemistry. 35:545-551 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/35.4.545 |
| Popis: | We present an algorithm for monitoring the concentration of human choriogonadotropin (hCG) in serum at various clinical decision levels with use of fast, simple, and cost-effective qualitative pregnancy test reagents for hCG in serum. Based on correlation between laboratory data and clinical observations described in the literature, the following concentrations of hCG in serum can be considered as clinically significant decision levels: 5 int. units/L to exclude or "rule out" the presence of increased hCG; 25 int. units/L for "confirming pregnancy" or confirming the presence of increased hCG from sources other than the trophoblast; and 6500 and 82 500 int. units/L to enhance the sonographic diagnoses of ectopic pregnancies and molar pregnancies, respectively. We used Tandem Icon II (Hybritech) pregnancy test reagents and evaluated the reagents for possible "false-positive" findings at the 25 int. units/L limit of hCG detectability by analyzing 100 post-menopausal and more than 4000 premenopausal serum specimens. The performance of the reagents was validated also at 5 int. units/L and at limits of hCG detectability greater than 25 int. units/L. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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