Ghrelinergic Signaling in Ethanol Reward
| Autor: | Eliotte E. Garling, L.J. Zallar, R. Pastor, S. Abtahi, Paul J. Currie, Hannah M. Baumgartner |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Receptor expression media_common.quotation_subject digestive oral and skin physiology Appetite Nucleus accumbens Ventral tegmental area Reward system medicine.anatomical_structure Endocrinology Hypothalamus Internal medicine medicine Ghrelin Receptor Psychology hormones hormone substitutes and hormone antagonists media_common |
| DOI: | 10.1016/b978-0-12-805373-7.00013-x |
| Popis: | While considerable work implicates the gastric peptide ghrelin in the neurohormonal control of appetite, more recent attention has focused on the peptide's role in the modulation of drug reward, including mechanisms mediating ethanol reinforcement. Ghrelin receptors are expressed within anatomical regions of the mesolimbic reward system, and both systemic and central ghrelin injections elicit robust increases in ethanol intake in rodent models. Such stimulatory effects are blocked by ghrelin receptor antagonism or modification to endogenous ghrelin receptor expression. Clinical studies further support the role of ghrelin signaling in human ethanol consumption, craving, and dependence. Overall, these lines of human and animal investigations provide compelling evidence implicating ghrelin as a potent signal in ethanol reinforcement, and may further identify a potential target in the pharmacotherapy of ethanol dependence and abuse. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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