Hydrophobic Regions on the Active Surface of Choline-esterases

Autor:	V. I. Rozengart, E. V. Rozengart, S. S. Mikhailov, R. V. Sitkevich, A. A. Abduvakhabov, E. I. Godyna, A. P. Brestkin, M. I. Kabachnik, Godovikov Nn, Volkova Ri, M Ya Mikhel'son, I. I. Agabekova
Rok vydání:	1970
Předmět:	chemistry.chemical_classification Aryl Substrate (chemistry) Sorption General Chemistry Active surface Esterase chemistry.chemical_compound Enzyme chemistry medicine Choline Organic chemistry Acetylcholine medicine.drug
Zdroj:	Russian Chemical Reviews. 39:485-497
ISSN:	1468-4837 0036-021X
DOI:	10.1070/rc1970v039n06abeh002001
Popis:	The methods of synthesis of S-alkyl(aryl) derivatives of methylphosphonothioic acid and methods for the investigation of their anticholine-esterase activity have been briefly described. Data confirming the anticholine-esterase activity of the compounds synthesised are presented. It has been shown that, in the inhibition of choline-esterases by organophosphorus compounds, the hydrophobic sorption of these substances on the active surface of the enzymes plays an important and sometimes a decisive role. It is suggested that the presence of hydrophobic regions on the active surface of choline-esterases tends to increase the probability of the sorption of acetylcholine (a choline esterase substrate) on this surface. The bibliography includes 68 references.
Databáze:	OpenAIRE
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