Bioavailability of Flavonoids in Ginkgo biloba Extract-γ-Cyclodextrin Complex
| Autor: | Masamitsu Moriwaki, Etsuko Tominaga, Kento Kito, Ryo Nakagawa, Mahendra P. Kapoor, Yoshiki Matsumiya, Tomohisa Fukuhara, Junya Kobayashi, Kensuke Satomoto, Hiroshi Yamagata, Yuichi Kuroiwa |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Natural Product Communications. 18:1934578X2311702 |
| ISSN: | 1555-9475 1934-578X |
| Popis: | Ginkgo biloba extract (GBE) is an essential herbal supplement for diverse health perspectives. The present study aims to improve the oral bioavailability of GBE flavonoids. We formulated the GBE flavonoids-cyclodextrin (GBE-CD) complex by reacting GBE flavonoids with naringinase in the presence of γ-cyclodextrin (CD) using a patented method. The results showed an enhanced bioavailability of quercetin (QCT), kaempferol (KAE), and isorhamnetin (ISR) after β-glucuronidase catalysis of flavonoid glucuronide conjugates in plasma after GBE-CD (25 μmol/kg as QCT equivalence) administration, that was 5.4, 6.1, and 10.4-folds, respectively, compared to GBE administration (25 μmol/kg as QCT equivalence) in Sprague–Dawley rats. In summary, the GBE inclusion into the γ-CD cavity is found suitable to improve oral bioavailability and could be applicable to several health benefits and disease prevention. |
| Databáze: | OpenAIRE |
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