Antioxidant property ofRubia cordifolia extract and its comparison with vitamin E and parabenzoquinone

Autor:	Savita Shukla, Yamini B. Tripathi, V. K. Shukla, Mukta Sharma
Rok vydání:	1995
Předmět:	Pharmacology Antioxidant biology medicine.medical_treatment Vitamin E Glutathione Pharmacognosy biology.organism_classification Malondialdehyde Lipid peroxidation chemistry.chemical_compound chemistry Biochemistry Cumene hydroperoxide Rubia cordifolia medicine
Zdroj:	Phytotherapy Research. 9:440-443
ISSN:	1099-1573 0951-418X
DOI:	10.1002/ptr.2650090611
Popis:	This report investigates the antioxidant properties of R. cordifolia extract for protection against lipid peroxidation and reduced glutathione (GSH) content in rat liver homogenate compared with vitamin E and parabenzoquinone (PBQ). R. cordifolia protects against depletion of glutathione in a dose and time dependent manner, an inverse correlation was observed between reduced glutathione depletion and malondialdehyde (MDA) formation. Interestingly, parabenzoquinone showed a better response than R. cordifolia on cumene hydroperoxide (CHP) induced malon-dialdehyde (MDA) release but there was no response in the rate of reduced glutathione (GHS) depletion. Thus it appears that R. cordifolia is a potent antiperoxidative and antioxidant. The mechanism of action is different to that of vitamin E and parabenzoquinone (PBQ).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bc15ae3cc6b56bd124c7b6af6535cbdd https://doi.org/10.1002/ptr.2650090611 Zobrazit plný text záznamu Plný text