HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus
| Autor: | Valentina Mereu, Roberto Broccoletti, Alessandra Elia, Antonio Amoroso, Marco Carrozzo, S. Rendine, Ennia Dametto, Maria Edvige Fasano |
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| Rok vydání: | 2010 |
| Předmět: |
Hepatitis C virus
Killer-cell immunoglobulin-like receptor virus diseases Hepatitis C Biology medicine.disease medicine.disease_cause Virology digestive system diseases Virus stomatognathic diseases HLA-C stomatognathic system Otorhinolaryngology Genotype Immunology medicine Oral lichen planus Allele General Dentistry |
| Zdroj: | Oral Diseases. 17:309-313 |
| ISSN: | 1354-523X |
| DOI: | 10.1111/j.1601-0825.2010.01742.x |
| Popis: | Oral Diseases (2011) 17, 309–313 Objectives: Oral Lichen Planus (OLP) is associated with hepatitis C virus (HCV) infection and resembles graft-versus-host disease (GVHD) both clinically and histologically. The killer cell immunoglobulin-like receptor (KIR) genes encode a family of receptors expressed on NK and T cells and are supposed to play a significant role in GVHD and HCV infection. The aim of this study was to analyze the association among OLP, HCV infection and variants in KIR gene expression. Methods: A total of 81 patients with OLP (36 HCV+ve and 45 HCV−ve) and 217 healthy controls (HCV−ve) were typed for the presence of eight KIR genes and of HLA-Cw* alleles by polymerase chain reaction-sequence specific primer. Results: There were no significant differences in the frequency of the KIR genes and HLA-C1/C2 group alleles between cases and controls. We only found a significant difference in the frequency of the gene KIR2DL2 between HCV+ve and HCV−ve OLP patients. Conclusions: The present data suggest that OLP is not associated with particular KIR genes or with HLA-Cw* alleles in patients without HCV infection. Contrarily, the role of the genes in OLP-HCV+ve patients remains unclear and might warrant further researches. |
| Databáze: | OpenAIRE |
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