Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers
| Autor: | Jia-Rong Xie, Zhifeng Xue, Zhidong Liu, Yixiao Dong, Zhe Ma, Jiawei Li, Xinru Sun, Dereje Kebebe Borga, Hong-Li Yan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug
media_common.quotation_subject Biophysics Pharmaceutical Science Nanoparticle Bioengineering Nanotechnology 02 engineering and technology Carbon nanotube 010402 general chemistry 01 natural sciences law.invention Biomaterials In vivo law Drug Discovery media_common Chemistry Organic Chemistry General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Anti tumor drug Toxicity Surface modification 0210 nano-technology Drug carrier |
| Zdroj: | International Journal of Nanomedicine. 14:10179-10194 |
| ISSN: | 1178-2013 |
| Popis: | Nanoparticle drug formulations have enormous application prospects owing to achievement of targeted and sustained release drug delivery, improvement in drug solubility and reduction of adverse drug reactions. Recently, a variety of efficient drug nanometer carriers have been developed, among which carbon nanotubes (CNT) have been increasingly utilized in the field of cancer therapy. However, these nanotubes exert various toxic effects on the body due to their unique physical and chemical properties. CNT-induced toxicity is related to surface modification, degree of aggregation in vivo, and nanoparticle concentration. This review has focused on the potential toxic effects of CNTs utilized as anti-tumor drug carriers. The main modes by which CNTs enter target sites, the toxicity expressive types and the factors affecting toxicity are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|