Curcumin Pretreatment Decreases Absorption of Phenacetin (Cytochrome P450 1A2 Substrate), Without Altering its Disposition Kinetics in Rats
| Autor: | Ch. Vivek, V. Venkatesh Prasad, M. Arjuna Rao, Gatha S. Rao |
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| Rok vydání: | 2016 |
| Předmět: |
Chemistry
Metabolite CYP1A2 Cmax Metabolism Absorption (skin) Pharmacology urologic and male genital diseases 030226 pharmacology & pharmacy female genital diseases and pregnancy complications 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics Phenacetin 030220 oncology & carcinogenesis medicine Curcumin General Agricultural and Biological Sciences General Environmental Science medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. 87:1293-1297 |
| ISSN: | 2250-1746 0369-8211 |
| DOI: | 10.1007/s40011-016-0706-2 |
| Popis: | Many drugs used in the therapeutic regimen for various ailments undergo metabolism via cytochrome P450 1A2 (CYP1A2), so the agents or conditions altering the expression and/or activity of this enzyme play a significant role in therapeutic efficacy/failure of its substrates. Though curcumin is reported to be an inhibitor of CYP1A2, influence of curcumin on the pharmacokinetics of CYP1A2 probe phenacetin in rats has not yet been published to the best of our knowledge. Hence an attempt has been made to investigate the same. Two groups of wistar albino rats were taken, of which, one group received curcumin at 400 mg kg−1, per os (PO) followed by phenacetin (150 mg kg−1, PO) and the other received only phenacetin. Plasma concentrations of phenacetin, a known CYP1A2 substrate and its metabolite paracetamol were determined by high performance liquid chromatography. Based on plasma concentrations, the pharmacokinetic parameters were determined by compartmental methods. Curcumin pretreatment significantly (P |
| Databáze: | OpenAIRE |
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