The efficiency of 18F labelling of a prostate specific membrane antigen ligand via strain-promoted azide–alkyne reaction: reaction speed versus hydrophilicity
Autor: | Vladimir V. Popik, Xiaofen Ma, Zhanhong Wu, Zibo Li, Hui Wang, Mengzhe Wang, Christopher D. McNitt, Sarah M. Scarry |
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Rok vydání: | 2018 |
Předmět: |
chemistry.chemical_classification
Bicyclic molecule 010405 organic chemistry Chemistry Ligand Kinetics Metals and Alloys Alkyne General Chemistry urologic and male genital diseases 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Antigen In vivo Labelling Materials Chemistry Ceramics and Composites Biophysics Azide |
Zdroj: | Chemical Communications. 54:7810-7813 |
ISSN: | 1364-548X 1359-7345 |
DOI: | 10.1039/c8cc03999b |
Popis: | Here we report the 18F labeling of a prostate specific membrane antigen (PSMA) ligand via a strain promoted oxa-dibenzocyclooctyne (ODIBO)- or bicyclo[6.1.0]nonyne (BCN)-azide reaction. Although ODIBO reacts with azide 20 fold faster than BCN, in vivo PET imaging suggests that 18F-BCN-azide-PSMA demonstrated much higher tumor uptake and a much higher tumor to background contrast. |
Databáze: | OpenAIRE |
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