The Incompatibilities Between Chlorhexidine Diacetate and Some Tablet Excipients
| Autor: | Timo Pesonen, Harri Kanerva, Jouni Hirvonen, Tuomo Nuuja, Juhani Pohjola, T. Rhodes |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
Chlorhexidine diacetate Absorption of water Sodium Organic Chemistry Sodium lauryl sulphate Pharmaceutical Science Mineralogy chemistry.chemical_element chemistry.chemical_compound chemistry Drug Discovery Sodium Starch Glycolate Relative humidity Magnesium stearate Powder mixture Nuclear chemistry |
| Zdroj: | Drug Development and Industrial Pharmacy. 21:747-752 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.3109/03639049509048139 |
| Popis: | The incompatibilities in a powder mixture for the manufacture of a chewable direct compression antiplague tablet preparate, were studied. The degree of loss of chlorhexi-dine diacetate in the presence of some common tablet exci-pients was studied under high relative humidity (80 % RH) and in water solution.The most significant losses in water solution were observed with lubricants magnesium stearate and sodium lauryl sulphate. Under high relative humidity the greatest losses were, on the contrary, observed with the materials having a great water absorption capacity, such as sodium carboxy-methylcellulose and sodium starch glycolate. |
| Databáze: | OpenAIRE |
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