Allogeneic Tumor-Syngeneic Muscle Sandwich Grafts: A Method for Promoting Nonspecific Growth 2

Autor:	Richard C. Parks
Rok vydání:	1976
Předmět:	C57BL/6 Cancer Research Pathology medicine.medical_specialty Strain (injury) Biology medicine.disease biology.organism_classification Blockade BALB/c Oncology Afferent Host organism medicine Neoplasm Skin allografts
Zdroj:	JNCI: Journal of the National Cancer Institute. 56:1281-1284
ISSN:	1460-2105 0027-8874
DOI:	10.1093/jnci/56.6.1281
Popis:	In H-2-incompatible mice, four strain-specific transplantable murine tumors grew when sandwiched between layers of muscle syngeneic to the intended recipient. The allogeneic tumor-syngeneic muscle sandwich (TMS) graft did not grow in recipients presensitized to the allogeneic tumor and in recipients immunized concurrently with tumor or skin allografts from the same strain as the sandwiched tumor. Third-party muscle, allogeneic to both tumor and host, also was effective in promoting nonspecific growth. The escape of the allogeneic tumor from immunologic destruction when it was implanted as a TMS graft may have been due to an afferent blockade.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bbed5c9be0575c93953c2d72134f0738 https://doi.org/10.1093/jnci/56.6.1281 Zobrazit plný text záznamu