Comparative Therapeutic Efficiency of Sulfapyridine and Sulfathiazole in Mice Infected with Pneumococcus Types II and III

Autor:	J. C. Moetsch, M. Severac, George W. Raiziss
Rok vydání:	1941
Předmět:	Blood level Oral dose Drug Chemistry media_common.quotation_subject Therapeutic effect Absorption (skin) Sulfapyridine Pharmacology General Biochemistry Genetics and Molecular Biology Sulfathiazole Toxicity Immunology medicine medicine.drug media_common
Zdroj:	Experimental Biology and Medicine. 46:361-363
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-46-11993p
Popis:	SummaryStudies of the toxicity disclose that sulfathiazole administered per os to rabbits is less toxic than sulfapyridine. On the other hand, administered the same way to mice sulfapyridine appeared to be less toxic than sulfathiazole. It is obvious that the absorption and elimination, and the resulting toxicity of the drug depend upon the species of animal used. In Types II and III pneumococcus infection, the therapeutic effect of sulfapyridine is superior to that of sulfathiazole, based on the oral dose only and with no blood level determinations.
Databáze:	OpenAIRE
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