Pd-Catalyzed asymmetric transformations involving P*-mono- and P*,N-bidentate diamidophosphites derived from (2S,3S)-N 2,3-dimethyl-N 1-phenylpentane-1,2-diamine

Autor:	Vadim A. Davankov, Alexei A. Shiryaev, O. V. Potapova, I. V. Chuchelkin, I. M. Novikov, Konstantin N. Gavrilov, E. A. Rastorguev, Pavel V. Petrovskii, Sergey V. Zheglov
Rok vydání:	2012
Předmět:	chemistry.chemical_compound Denticity Chemistry Stereochemistry Diamine Enantioselective synthesis General Chemistry Medicinal chemistry Dimethyl malonate Desymmetrization Catalysis
Zdroj:	Russian Chemical Bulletin. 61:1925-1932
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-012-0267-3
Popis:	The synthesis of new P*-mono- and P*,N-bidentate diamidophosphites, containing 1,3,2-diazaphospholidine rings formed starting from (2S,3S)-N 2,3-dimethyl-N 1-phenylpentane-1,2-diamine, is described. Comparison of their efficiency in the Pd-catalyzed enantioselective allylation with (E)-1,3-diphenylallyl acetate showed that up to 97% ee was reached in the reaction involving dimethyl malonate as a C-nucleophile. The Pd-catalyzed desymmetrization of N,N′-ditosyl-meso-cyclopent-4-ene-1,3-diol biscarbamate gave up to 61% ee.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bbe857c4a846fa94f18d6e113f0ee3ec https://doi.org/10.1007/s11172-012-0267-3 Zobrazit plný text záznamu Full text from SpringerLink