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The purpose of the research is to study the chemical stability of triclabendazole (TCB) in preparations obtained by its mechanochemical modification with polymeric substances and succinic acid (SA), as well as samples of Triclafascid obtained in 2015–2022 and left for storage at a temperature of 18–25 0C and a relative humidity of 55–60%. To achieve this goal, we selected samples of preparations obtained earlier and in freshly prepared solid dispersions (SD) based on TCB, SA, polyvinylpyrrolidone (PVP) and arabinogalactan (AG). Modification of TCB by polymeric substances was carried out at a weight ratio of components 1:9 in an LE101 ball mill at a rotation speed of 65–70 rpm with sampling for stability (integrity) analysis of TCB by high performance liquid chromatography (HPLC). The integrity analysis of TCB in its SDs obtained in 2015–2022 showed that there was no chemical destruction of TCB in them. The TCB substance is a stable chemical molecule that is not affected by destruction either during machining or during succinic acid treatment. The obtained SDs remain stable for TCB during storage for more than 7 years. |
